hnRNP Q polyclonal, anti-human, mouse, rat

Background:
Pre-mRNA splicing is a critical step in the posttranscriptional regulation of gene expression. Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) is involved in RNA processing and is necessary for efficient pre-mRNA splicing. hnRNP is widely expressed and developmentally regulated. hnRNP Q interacts with survival motor neuron protein (SMN). Loss of function of SMN results in spinal muscular atrophy, a common neurodegenerative disease. The most common deletion in SMN genes disrupts the interaction between SMN and hnRNP Q. hnRNP Q is upregulated after midnight, and this upregulation correlates with an abrupt decline in AANAT, the key enzyme in melatonin synthesis. Rhythmic AANAT mRNA degradation mediated in part by hnRNP Q implicates this enzyme in the regulation of circadian oscillation.

Alternative Name:
hnRNP Q, GRY-RBP, SYNCRIP, HNRPQ, NSAP1, cytoplasmic RNA-interacting protein, dJ3J17.2, Glycine and tyrosine rich RNA binding protein, Glycine- and tyrosine-rich RNA-binding protein, GRY RBP, GRY-RBP, GRYRBP, Heterogeneous nuclear ribonucleoprotein Q, hnRNP Q, HNRPQ, HNRPQ, HNRPQ1, NS1 associated protein 1, NS1-associated protein 1, NSAP1, pp68, RP1 3J17.2, Synaptotagmin binding cytoplasmic RNA interacting protein, Synaptotagmin-binding, Syncrip,

Application Dilution:
WB:1:500-1:2,000
ICC:1:50-1:200
IHC:1:50-1:200

Specificity: hnRNP Q polyclonal antibody detects endogenous levels of hnRNP Q protein.

Immunogen:
Recombinant protein to C-terminal human hnRNP Q.

MW: 70 kDa

Swiss-Prot: O60506(Human) Q7TP47(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.