HORMAD2 Polyclonal Antibody

Background:
Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break-independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex body formation (By similarity).

Research Area: Cell Biology

Synonyms:
4930529M09Rik, CT46.2, HORM2, HORMA domain containing 2, HORMA domain-containing protein 2, Hormad2, MGC26710, RP23-329P17.4

Immunogen: Fusion protein of human HORMAD2

Swissprot: Q8N7B1
Gene Accession: BC030013

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 1.32 mg/mL
Dilution: IHC 1:50-1:200, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.