Hox A13 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS71336
Background:
HoxA13 and HoxD13 also bind to other BMP and TGF-beta/Activin-regulated Smad proteins including Smad1 and Smad2, but not Smad4. In humans and mice, loss of HOXA13 function causes defects in the growth and patterning of the digits and interdigital tissues. Analysis of HoxA13 expression reveals a pattern of localization overlapping with sites of reduced Bmp2 and Bmp7 expression in HoxA13 mutant limbs. HoxA13 regulates Bmp2 and Bmp7 expression, providing a link between HoxA13, its target genes and the specific developmental processes affected by loss of HoxA13 function.
Alternative Name:
Homeobox protein Hox-A13, Homeobox protein Hox-1J, HOXA13, HOX1J
Application Dilution: WB: 1:1000 - 1:4000, IF: 1:50 - 1:200
Specificity: Hox A13 polyclonal antibody detects endogenous levels of Hox A13 protein.
Immunogen:
Recombinant protein of human HOXA13.
MW: ~ 40 kDa
Swis Prot.: P31271
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
HoxA13 and HoxD13 also bind to other BMP and TGF-beta/Activin-regulated Smad proteins including Smad1 and Smad2, but not Smad4. In humans and mice, loss of HOXA13 function causes defects in the growth and patterning of the digits and interdigital tissues. Analysis of HoxA13 expression reveals a pattern of localization overlapping with sites of reduced Bmp2 and Bmp7 expression in HoxA13 mutant limbs. HoxA13 regulates Bmp2 and Bmp7 expression, providing a link between HoxA13, its target genes and the specific developmental processes affected by loss of HoxA13 function.
Alternative Name:
Homeobox protein Hox-A13, Homeobox protein Hox-1J, HOXA13, HOX1J
Application Dilution: WB: 1:1000 - 1:4000, IF: 1:50 - 1:200
Specificity: Hox A13 polyclonal antibody detects endogenous levels of Hox A13 protein.
Immunogen:
Recombinant protein of human HOXA13.
MW: ~ 40 kDa
Swis Prot.: P31271
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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