HP polyclonal (Center), anti-human, mouse
€0.00
In stock
SKU
AC-AP10680C
Catalog Number: AC-AP10680C
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB28443
Applications: IHC-P-Leica, WB, IF, FC
Datasheet
Request Information
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB28443
Applications: IHC-P-Leica, WB, IF, FC
Datasheet
Request Information
Background:
This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene.
Other Names:
Haptoglobin, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain, HP
Target/Specificity:
This HP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-322 amino acids from the Central region of human HP.
Antigen Region:
296-322
Antigen Type: Synthetic Peptide
Gene Name: HP
Gene ID: 3240
Primary Accession: P00738
NCBI Accession: NP_001119574.1;NP_005134.1
Other Accession: NP_005134.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene.
Other Names:
Haptoglobin, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain, HP
Target/Specificity:
This HP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-322 amino acids from the Central region of human HP.
Antigen Region:
296-322
Antigen Type: Synthetic Peptide
Gene Name: HP
Gene ID: 3240
Primary Accession: P00738
NCBI Accession: NP_001119574.1;NP_005134.1
Other Accession: NP_005134.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
|---|
Write Your Own Review