HP1-α (clone 3G2-H10-A6), anti-human, mouse

Background:
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Synonyms: HEL25, HP1, HP1A

Cellular Location: Chromosome Nucleus centromere

Immunogen:
Purified recombinant human HP1 alpha protein fragments expressed in E.coli.

Gene Symbol: HP1-α

Gene ID: 23468

Swiss prot: P45973

Calculated MW: 26kDa

Recommended dilution:
WB 1:1000, ICC 1:300

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.