HRAS Polyclonal Antibody

Background:
This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene.

Research Area: Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Signal Transduction

Synonyms:
C BAS/HAS, c H ras, C HA RAS1, c has/bas p21 protein, c ras Ki 2 activated oncogene, c-H-ras, CTLO, GTP and GDP binding peptide B, GTPase HRas, N-terminally processed, H Ras 1, H RASIDX, H-Ras-1, Ha Ras, Ha Ras1 proto oncoprotein, Ha-Ras, HAMSV, Harvey rat sarcoma viral oncogene homolog, Harvey rat sarcoma viral oncoprotein, HRAS, HRAS1, K ras, N ras, p19 H RasIDX protein, p21ras, Ras family small GTP binding protein H Ras, RASH, RASH1, Transformation gene oncogene HAMSV, Transforming protein p21, v Ha ras Harvey rat sarcoma viral oncogene homolog, VH Ras, vHa RAS

Immunogen: Synthetic peptide of human HRAS

Swissprot: P01112
Gene Accession: NP001123914

Calculated MW: 21 kDa
Observed MW: Refer to figures

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.66 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:25-1:50, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.