HRI (EIF2AK1) Antibody (C-term) Blocking peptide
€363.00
In stock
SKU
AC-BP8114b
Background:
Eukaryotic translation initiation factor 2-alpha kinase 1 (EIF2AK1) belongs to the protein kinase superfamily, Ser/Thr protein kinase family, GCN2 subfamily. It mediates down-regulation of protein synthesis in response to various stress conditions by the phosphorylation of EIF2S1 at Ser-48 and Ser-51. Hemin inactivates EIF2AK1 by promoting the formation of a disulfide-linked homodimer. The homodimer is non-covalently bound in the absence of hemin, and converted to an inactive disulfide linked homodimer in the presence of hemin. Binding of nitric oxide (NO) to the heme iron in the N-terminal heme-binding domain activates the kinase activity, while binding of carbon monoxide (CO) suppresses kinase activity. EIF2AK1 is activated by autophosphorylation; phosphorylated predominantly on serine and threonine residues, but also on tyrosine residues.
Other Names:
Eukaryotic translation initiation factor 2-alpha kinase 1, Heme-controlled repressor, HCR, Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase, Heme-regulated inhibitor, Hemin-sensitive initiation factor 2-alpha kinase, EIF2AK1, HRI, KIAA1369
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP8114b was selected from the C-term region of human EIF2AK1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: EIF2AK1 (HGNC:24921)
Gene ID: 27102
Primary Accession: Q9BQI3
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Eukaryotic translation initiation factor 2-alpha kinase 1 (EIF2AK1) belongs to the protein kinase superfamily, Ser/Thr protein kinase family, GCN2 subfamily. It mediates down-regulation of protein synthesis in response to various stress conditions by the phosphorylation of EIF2S1 at Ser-48 and Ser-51. Hemin inactivates EIF2AK1 by promoting the formation of a disulfide-linked homodimer. The homodimer is non-covalently bound in the absence of hemin, and converted to an inactive disulfide linked homodimer in the presence of hemin. Binding of nitric oxide (NO) to the heme iron in the N-terminal heme-binding domain activates the kinase activity, while binding of carbon monoxide (CO) suppresses kinase activity. EIF2AK1 is activated by autophosphorylation; phosphorylated predominantly on serine and threonine residues, but also on tyrosine residues.
Other Names:
Eukaryotic translation initiation factor 2-alpha kinase 1, Heme-controlled repressor, HCR, Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase, Heme-regulated inhibitor, Hemin-sensitive initiation factor 2-alpha kinase, EIF2AK1, HRI, KIAA1369
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP8114b was selected from the C-term region of human EIF2AK1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: EIF2AK1 (HGNC:24921)
Gene ID: 27102
Primary Accession: Q9BQI3
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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