HS71A polyclonal, anti-human

Background:
In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response.

Synonyms: ABL, JTK7, bcr/abl, c-ABL, c-ABL1, p150, v-abl

Cellular Location: Cytoskeleton Nucleus

Immunogen:
A synthetic peptide of human HS71A

Gene Symbol: HS71A

Gene ID: 3303/3304.

Swiss prot: P0DMV8

Calculated MW: 70kDa

Recommended dilution:
WB 1:2500

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.