HSC70 Interacting Protein HIP polyclonal, anti-human

Quantity: 100 µg

Background:
ST13(Suppression of Tumorigenicity 13), also known as P48 or HIP, is a protein that in humans is encoded by the ST13 gene. ST13 is an abundant, highly conserved protein that binds the major cytosolic chaperones heat-shock protein 70-kD(HSP70) and HSP90 during an intermediate stage of steroid receptor assembly, but is absent from the mature receptor complex. Zhang et al.(1998) mapped the ST13 gene to chromosome 22q13 by fluorescence in situ hybridization. They noted that colorectal, breast, and ovarian carcinomas frequently show loss of heterozygosity at this site. Using a yeast 2-hybrid assay, Hohfeld et al.(1995) showed that rat Hip bound Hsc70(HSPA8). One Hip oligomer bound the ATPase domains of at least 2 Hsc70 molecules, and binding was dependent on activation of the Hsc70 ATPase by Hsp40(DNAJB1). Hip stabilized the ADP-bound form of Hsc70, which had a high affinity for a test protein substrate. Hohfeld et al.(1995) concluded that HIP contributes to interactions of HSC70 with target proteins through its own chaperone activity.

Description:
Rabbit IgG polyclonal antibody for Hsc70-interacting protein (ST13) detection. Tested with WB in Human.

Synonyms:
AAG 2 antibody, AAG2 antibody, Aging associated protein 2 antibody, F10A1_HUMAN antibody, FAM10A1 antibody, FAM10A4 antibody, FLJ27260 antibody, Heat shock 70kD protein binding protein antibody, HIP antibody, HOP antibody, Hsc70 interacting protein antibody, Hsc70-interacting protein antibody, Hsp70 interacting protein antibody, HSPABP 1 antibody, HSPABP antibody, HSPABP1 antibody, MGC129952 antibody, OTTHUMP00000028873 antibody, P48 antibody, PRO0786 antibody, Progesterone receptor associated p48 protein antibody, Progesterone receptor-associated p48 protein antibody, Protein FAM10A1 antibody, Putative tumor suppressor ST13 antibody, Renal carcinoma antigen NY REN 33 antibody, Renal carcinoma antigen NY-REN-33 antibody, SNC 6 antibody, SNC6 antibody, ST 13 antibody, ST13 antibody, Suppression of tumorigenicity 13 antibody, Suppression of tumorigenicity 13(colon carcinoma) antibody, Suppression of tumorigenicity 13 protein antibody, Suppression of tumorigenicity protein 13 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminus of human ST13(1-19aa MDPRKVNELRAFVKMCKQD), different from the related rat and mouse sequences by two amino acids.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.