Hsc70 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
HSPA8 (heat shock 70kDa protein 8) also known as HSC70, HSC71, HSP73, HSPA10, FORMERLY, LAP1 or LPS-ASSOCIATED PROTEIN 1, is a heat shock protein that in humans is encoded by the HSPA8 gene. The HSPA8 gene contains 9 exons and spans 5 kb. The deduced HSPA8 protein has 646 amino acids and a predicted molecular mass of 70,899 Da. And the HSPA8 gene is mapped on 11q24.1. HSPA8 plays an important role in cells by transiently associating with nascent polypeptides to facilitate correct folding. HSP73 also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Rapid decay involves AU-rich binding protein AUF1, which complexes with heat-shock proteins HSC70 and HSP70, translation initiation factor EIF4G, and poly (A)-binding protein. In the absence of Il3, Hsc70 formed a complex with Hsp40 and Hip, and this complex, in association with Eif4g and Pabp, formed a high-stability complex with Bim mRNA that protected it from ribonucleases.

Description:
Rabbit IgG polyclonal antibody for Heat shock cognate 71 kDa protein (HSPA8) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
2410008N15Rik antibody, Constitutive heat shock protein 70 antibody, Heat shock 70 kDa protein 8 antibody, Heat shock 70kD protein 10 antibody, Heat shock 70kD protein 8 antibody, Heat shock 70kDa protein 8 antibody, Heat shock cognate 71 kDa protein antibody, Heat shock cognate 71 kDa protein. antibody, Heat shock cognate protein 54 antibody, Heat shock cognate protein 71 kDa antibody, Heat shock cognate protein 71-kDa antibody, Heat shock protein 8 antibody, Heat shock protein A8 antibody, Heat-shock70-KD protein 10, formerly antibody, HSC54 antibody, HSC71 antibody, Hsc73 antibody, HSP71 antibody, HSP73 antibody, HSP7C_HUMAN antibody, HSPA10 antibody, HSPA8 antibody, LAP1 antibody, Lipopolysaccharide associated protein 1 antibody, LPS associated protein 1 antibody, LPS associated protein antibody, MGC102007 antibody, MGC106514 antibody, MGC114311 antibody, MGC118485 antibody, MGC131511 antibody, MGC29929 antibody, N-myristoyltransferase inhibitor protein 71 antibody, NIP71 antibody.

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human Hsc70 recombinant protein (Position: Q520-A614). Human Hsc70 shares 98.9% amino acid (aa) sequence identity with both mouse and rat Hsc70.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.