HSD11B1 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
11beta-hydroxysteroid dehydrogenase type 1 is an NADPH-dependent enzyme highly expressed in key metabolic tissues including liver, adipose tissue, and the central nervous system. In these tissues, HSD11B1 reduces cortisone to the active hormone cortisol that activates glucocorticoid receptors. It is inhibited by carbenoxolone, a drug typically used in the treatment of peptic ulcers. Tannin et al.(1991) localized the HSD11B1 gene to chromosome 1. The localization was confirmed by isolating the gene from a chromosome 1-specific library using the cDNA as a probe. Schutte et al.(2000) mapped the HSD11B1 gene to 1q32-q41.

Description:
Rabbit IgG polyclonal antibody for Corticosteroid 11-beta-dehydrogenase isozyme 1 (HSD11B1) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
11 beta HSD 1 antibody, 11 beta HSD1 antibody, 11 beta hydroxysteroid dehydrogenase 1 antibody, 11 DH antibody, 11-beta hydroxysteroid dehydrogenase, type 1 antibody, 11-beta-HSD1 antibody, 11-beta-hydroxysteroid dehydrogenase 1 antibody, 11-DH antibody, 11DH antibody, Corticosteroid 11 beta dehydrogenase isozyme 1 antibody, Corticosteroid 11-beta-dehydrogenase isozyme 1 antibody, CORTRD2 antibody, DHI1_HUMAN antibody, HDL antibody, HSD 11 antibody, HSD11 antibody, HSD11B antibody, HSD11B1 antibody, HSD11L antibody, Hydroxysteroid(11 beta) dehydrogenase 1 antibody, Hydroxysteroid(11 beta) dehydrogenase antibody, MGC13539 antibody, SDR26C1 antibody, short chain dehydrogenase/reductase family 26C, member 1 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminus of human HSD11B1(16-33aa MAYYYYSANEEFRPEMLQ), different from the related mouse sequence by two amino acids, and from the related rat sequence by four amino acids.A synthetic peptide corresponding to a sequence at the N-terminus of human HSD11B1(16-33aa MAYYYYSANEEFRPEMLQ), different from the related mouse sequence by two amino acids, and from the related rat sequence by four amino acids.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat
Predicted to work with: mouse

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.