HSD11B1 Polyclonal Antibody

Background:
The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.

Research Area: Cancer, Metabolism, Signal Transduction

Synonyms:
11 beta HSD 1, 11 beta HSD1, 11 beta hydroxysteroid dehydrogenase 1, 11 DH, 11-beta hydroxysteroid dehydrogenase, type 1, 11-beta-HSD1, 11-beta-hydroxysteroid dehydrogenase 1, 11-DH, 11DH, Corticosteroid 11 beta dehydrogenase isozyme 1, Corticosteroid 11-beta-dehydrogenase isozyme 1, CORTRD2, DHI1, HDL, HSD 11, HSD11, HSD11B, HSD11B1, HSD11L, Hydroxysteroid (11 beta) dehydrogenase, Hydroxysteroid (11 beta) dehydrogenase 1, MGC13539, SDR26C1, short chain dehydrogenase/reductase family 26C, member 1

Immunogen: Fusion protein of human HSD11B1

Swissprot: P28845
Gene Accession: BC012593

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 1.2 mg/mL
Dilution: IHC 1:50-1:200, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.