HSD11B2 Polyclonal Antibody

Background:
There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor.

Research Area: Cancer, Cell Biology, Cardiovascular, Metabolism, Signal Transduction

Synonyms:
11 beta HSD2, 11 beta hydroxysteroid dehydrogenase type 2, 11 DH2, 11-beta-HSD2, 11-beta-hydroxysteroid dehydrogenase type 2, 11-DH2, AME, AME1, Corticosteroid 11 beta dehydrogenase isozyme 2, Corticosteroid 11-beta-dehydrogenase isozyme 2, DHI2, HSD11B2, HSD11K, HSD2, Hydroxysteroid 11 beta dehydrogenase 2, Hydroxysteroid 11 beta dehydrogenase isoenzyme 2, NAD dependent 11 beta hydroxysteroid dehydrogenase, NAD-dependent 11-beta-hydroxysteroid dehydrogenase, SDR9C3, Short chain dehydrogenase/reductase family 9C, member 3

Immunogen: Synthetic peptide of human HSD11B2

Swissprot: P80365
Gene Accession: NP_000187

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.6 mg/mL
Dilution: IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-19262/sc-19263/sc-20176