HSD11B2 Polyclonal Antibody

Background:
There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension.

Research Area: Cancer, Cell Biology, Cardiovascular, Metabolism, Signal Transduction

Synonyms:
HSD11B2, AME, AME1, HSD11K, HSD2, SDR9C3

Immunogen: Recombinant fusion protein of human HSD11B2 (NP_000187.3).

Swissprot: P80365
Gene ID: 3291

Calculated MW: 44 kDa
Observed MW: 44 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:200-1:1000 IHC 1:50-1:100"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.