HSD17B1 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
HSD17B1(17-BETA-HYDROXYSTEROID DEHYDROGENASE I), also known as 17-beta-hydroxysteroid dehydrogenase or 17-ketosteroid reductase, is an enzyme that is responsible for the interconversion of estrone(E1) and estradiol(E2) as well as the interconversion of androstenedione and testosterone. Its cytogenetic location is 17q21.2. HSD17B1 gene expression is detected in 34 of 42(81%) adenomas in all tumor subtypes; HSD17B2 mRNA is detected in 18 of 42(43%) adenomas but not in prolactinomas. Human estrogenic HSD17B1 is an NADP(H)-preferring enzyme. It possesses 11- and 4-fold higher specificity toward NADP(H) over NAD(H) for oxidation and reduction, respectively, as demonstrated by kinetic studies. All 4 HSD17B isoforms are variably expressed in human anterior pituitary adenomas, which also show HSD17B enzyme activity, suggesting that HSD17B may play an important role in regulating the local cellular levels of estradiol.

Description:
Rabbit IgG polyclonal antibody for Estradiol 17-beta-dehydrogenase 1 (HSD17B1) detection. Tested with WB, IHC-P, ICC in Human, Mouse, Rat.

Synonyms:
17 beta HSD 1 antibody, 17 beta hydroxysteroid dehydrogenase type 1 antibody, 17-beta-HSD 1 antibody, 17-beta-hydroxysteroid dehydrogenase type 1 antibody, 20 alpha-hydroxysteroid dehydrogenase antibody, 20-alpha-HSD antibody, DHB1_HUMAN antibody, E17KSR antibody, E2DH antibody, EDH17B1 antibody, EDH17B2 antibody, EDHB17 antibody, Estradiol 17 beta dehydrogenase 1 antibody, Estradiol 17-beta-dehydrogenase 1 antibody, HSD17 antibody, HSD17B1 antibody, Hydroxysteroid(17 beta) dehydrogenase 1 antibody, MGC13814 antibody, Placental 17 beta hydroxysteroid dehydrogenase antibody, Placental 17-beta-hydroxysteroid dehydrogenase antibody, SDR28C1 antibody, Short chain dehydrogenase/reductase family 28CE,member 1 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminus of human HSD17B1(29-43aa QSFKVYATLRDLKTQ), different from the related rat and mouse sequences by one amino acid.A synthetic peptide corresponding to a sequence at the N-terminus of human HSD17B1(29-43aa QSFKVYATLRDLKTQ), different from the related rat and mouse sequences by one amino acid.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat .
Predicted to work with: mouse.

Applications: WB, IHC-P, ICC

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.