HSD17B1 Polyclonal Antibody

Background:
Hydroxysteroid (17-beta) dehydrogenase 1 catalyzes the final step in the formation of estradiol and testosterone from estrone and androstenedione, respectively. Ovarian granulosa cells and breast tissue both express HSD17B1. Other tissues that express HSD17B1 include testis, placenta, uterus, prostate and adipose tissue. HSD17B1 functions as a homodimer and prefers NADP(H) over NAD(H) for oxidation and reduction. The gene encoding human HSD17B1 maps to chromosome 17q12-q21. The importance of HSD17B1 to estradiol production suggests the specific inhibition of HSD17B1 may aid in breast cancer therapy.

Research Area: Cancer, Metabolism, Neuroscience, Signal Transduction

Synonyms:
17 beta HSD 1, 17 beta hydroxysteroid dehydrogenase type 1, 17-beta-HSD 1, 17-beta-hydroxysteroid dehydrogenase type 1, 20 alpha-hydroxysteroid dehydrogenase, 20-alpha-HSD, DHB1, E17KSR, E2DH, EDH17B1, EDH17B2, EDHB17, Estradiol 17 beta dehydrogenase 1, Estradiol 17-beta-dehydrogenase 1, HSD17, HSD17B1, Hydroxysteroid (17 beta) dehydrogenase 1, MGC13814, Placental 17 beta hydroxysteroid dehydrogenase, Placental 17-beta-hydroxysteroid dehydrogenase, SDR28C1, Short chain dehydrogenase/reductase family 28CE, member 1

Immunogen: Synthetic peptide of human HSD17B1

Swissprot: P14061
Gene Accession: NP_000404

Calculated MW: 35 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.9 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-26964/sc-26963/sc-26965/sc-32872/sc-32871