HSD17B12 Polyclonal Antibody

Background:
This gene encodes a very important 17beta-hydroxysteroid dehydrogenase (17beta-HSD) that converts estrone into estradiol in ovarian tissue. This enzyme is also involved in fatty acid elongation. Catalyzes the transformation of estrone (E1) into estradiol (E2), suggesting a central role in estrogen formation. Its strong expression in ovary and mammary gland suggest that it may constitute the major enzyme responsible for the conversion of E1 to E2 in women.

Research Area: Cell Biology, Metabolism, Signal Transduction

Synonyms:
12, 3-ketoacyl-CoA reductase, short chain, 17 beta HSD 12, 17 beta hydroxysteroid dehydrogenase 12, 17-@beta-HSD XII, 17-@beta-hydroxysteroid dehydrogenase XII, 17-beta-HSD 12, 17-beta-hydroxysteroid dehydrogenase 12, 17beta HSD type 12, 3 ketoacyl CoA reductase, 3-ketoacyl-CoA reductase, DHB12, Estradiol 17 beta dehydrogenase 12, Estradiol 17-beta-dehydrogenase 12, HSD17B12, Hydroxysteroid (17-beta) dehydrogenase 12, KAR, KIK-I, Kik1, SDR12C1, Short chain dehydrogenase/reductase family 12C member 1, Steroid dehydrogenase homolog

Immunogen: Recombinant protein of human HSD17B12

Swissprot: Q53GQ0
Gene Accession: BC012043

Calculated MW: 34 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.3 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-161281/sc-161282