ANGP2 polyclonal, anti-human
€470.00
In stock
SKU
AC-AP74469
Background:
Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.
Other Names:
Angiopoietin-2 (ANG-2)
Antigen Type: synthetic peptide
Antigen Type: ANGPT2
Gene ID: 285
Primary Accession: O15123
Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.
Other Names:
Angiopoietin-2 (ANG-2)
Antigen Type: synthetic peptide
Antigen Type: ANGPT2
Gene ID: 285
Primary Accession: O15123
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