HSD17B2 polyclonal, anti-mouse, rat

Quantity: 100 µg

Background:
HSD17B2(17-BETA-HYDROXYSTEROID DEHYDROGENASE II), also called 17-BETA-HSD II, is an anzyme which have 387 amino acids with a predicted molecular weight of 42,782 and associate with the membranes of the endoplasmic reticulum. Its Cytogenetic location is 16q23.3. The type 2 enzyme was capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. HSD17B2 mRNA was detected in 18 of 42(43%) adenomas but not in prolactinomas. In the human endometrium, inactivation of 17-beta-estradiol to estrone is catalyzed by HSD17B2. And HSD17B2 activity distinguishing between disease-free and diseased endometria. HSD17B2 efficiently catalyzes the oxidative metabolism of androgens and estrogens, and it is expressed in a large series of human peripheral tissues. The previous paradigm that HSD17B2 activity in the endometrium is elevated during the secretory phase is confined to diseased endometrium but not to disease-free endometrium.

Description:
Rabbit IgG polyclonal antibody for Estradiol 17-beta-dehydrogenase 2 (HSD17B2) detection. Tested with WB, IHC-P in Mouse, Rat.

Synonyms:
17 beta HSD 2 antibody, 17-beta-HSD 2 antibody, 17-beta-hydroxysteroid dehydrogenase type 2 antibody, 20 alpha HSD antibody, 20 alpha hydroxysteroid dehydrogenase antibody, 20 alpha-hydroxysteroid dehydrogenase antibody, 20-alpha-HSD antibody, DHB2_HUMAN antibody, E2DH antibody, EDH17B2 antibody, Estradiol 17-beta-dehydrogenase 2 antibody, HSD17 antibody, Hsd17b2 antibody, Hydroxysteroid(17 beta) dehydrogenase 2 antibody, Microsomal 17 beta hydroxysteroid dehydrogenase antibody, Microsomal 17-beta-hydroxysteroid dehydrogenase antibody, SDR9C2 antibody, Testosterone 17 beta dehydrogenase antibody, Testosterone 17-beta-dehydrogenase antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of mouse HSD17B2(274-290aa QDIWDKMEKEILDHFSK), different from the related rat sequence by one amino acid.A synthetic peptide corresponding to a sequence at the C-terminus of mouse HSD17B2(274-290aa QDIWDKMEKEILDHFSK), different from the related rat sequence by one amino acid.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: mouse, rat

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.