HSD17B6 polyclonal, anti-human

Quantity: 100 µg

Background:
Hydroxysteroid 17-beta dehydrogenase 6 is an enzyme that in humans is encoded by the HSD17B6 gene. The protein encoded by this gene has both oxidoreductase and epimerase activities and is involved in androgen catabolism. Baker ME et al point out expression of 17beta-HSDs had an important role in the early evolution of the physiological response to androgens and estrogens. Biswas and Russell concluded that 17beta-HSD6 and RoDH play opposing roles in androgen action; 17beta-HSD6 inactivates 3alpha-adiol by conversion to androsterone and RoDH activates 3alpha-adiol by conversion to dihydrotestosterone. The synthesis of an active steroid hormone by back conversion of an inactive metabolite represents a potentially important mechanism by which the steady state level of a transcriptional effector can be regulated.

Description:
Rabbit IgG polyclonal antibody for 17-beta-hydroxysteroid dehydrogenase type 6 (HSD17B6) detection. Tested with WB, IHC-P in Human.

Synonyms:
17-beta-HSD 6 antibody, 17-beta-HSD6 antibody, 17-beta-hydroxysteroid dehydrogenase type 6 antibody, 3 hydroxysteroid epimerase antibody, 3(alpha>beta) hydroxysteroid epimerase antibody, 3(alpha>beta) hydroxysteroid epimerasel antibody, 3-alpha->beta-HSE antibody, 3-alpha->beta-hydroxysteroid epimerase antibody, H17B6_HUMAN antibody, HSD17B6 antibody, HSE antibody, Hydroxysteroid(17 beta) dehydrogenase 6 antibody, Hydroxysteroid(17 beta) dehydrogenase 6 homolog(mouse) antibody, Hydroxysteroid 17 beta dehydrogenase 6 antibody, NAD+ dependent 3 alpha hydroxysteroid dehydrogenase 3 hydroxysteroid epimerase antibody, NAD+ dependent 3 alpha hydroxysteroid dehydrogenase antibody, Oxidative 3 alpha hydroxysteroid dehydrogenase antibody, Oxidative 3-alpha hydroxysteroid dehydrogenase antibody, Oxidoreductase antibody, Retinol dehydrogenase antibody, RODH antibody, SDR9C6 antibody, Short chain dehydrogenase/reductase family 9C, member 6 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human HSD17B6(300-317aa SLADYILTRSWPKPAQAV).

Form: Liquid; Each vial contains 50% glycerol, 0.9mg NaCl, 0.2mg Na2HPO4.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB, IHC-P

Storage: At -20˚C for one year, at 4˚C for one month. Avoid repeated freezing and thawing.