Hsp105 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
HSP105(HEAT-SHOCK 105/110-KD PROTEIN 1), also called HSPH1 or HSP110, is a protein that in humans is encoded by the HSPH1 gene. Immunohistochemical analysis localizes HSP105 mainly in the cytoplasm. Database analysis indicates that both HSP105 isoforms are highly conserved during evolution. By analysis of radiation hybrids and human/rodent hybrid cell lines, the HSPH1 gene is mapped to chromosome 13. Both HSP105-alpha and HSP105-beta are upregulated in HeLa cells exposed to heat shock. HSP105-alpha, but not HSP105-beta, is also upregulate in response to other cell stresses. Following heat shock, HSP105 relocalizes from a cytoplasmic to perinuclear position. Besides, HSP110 may thus constitute a major determinant for both prognosis and treatment response in colorectal cancer.

Description:
Rabbit IgG polyclonal antibody for Heat shock protein 105 kDa (HSPH1) detection. Tested with WB, IHC-P, IHC-F in Human, Mouse, Rat.

Synonyms:
Antigen NY CO 25 antibody, Antigen NY-CO-25 antibody, DKFZp686M05240 antibody, Heat shock 105kD alpha antibody, Heat shock 105kD antibody, Heat shock 105kD beta antibody, Heat shock 105kDa protein 1 antibody, Heat shock 105kDa protein antibody, Heat shock 105kDa/110kDa protein 1 antibody, Heat shock 110 kDa protein antibody, Heat shock 110kDa protein antibody, Heat shock protein 105 kDa antibody, HS105_HUMAN antibody, HSP105 antibody, HSP105A antibody, HSP105B antibody, HSP110 antibody, HSPH 1 antibody, HSPH1 antibody, KIAA0201 antibody, NY CO 25 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human Hsp105(713-733aa EVMEWMNNVMNAQAKKSLDQD), different from the related mouse sequence by one amino acid, and different from the related rat sequence by two amino acids.A synthetic peptide corresponding to a sequence at the C-terminus of human Hsp105(713-733aa EVMEWMNNVMNAQAKKSLDQD), different from the related mouse sequence by one amino acid, and different from the related rat sequence by two amino acids.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat .
Predicted to work with: mouse.

Applications: WB, IHC-P, IHC-F

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.