HSP105 polyclonal, anti-human, mouse, rat

Background:
The heat shock proteins (HSPs) comprise a group of highly conserved, abundantly expressed proteins with diverse functions, including the assembly and sequestering of multiprotein complexes, transportation of nascent poly-peptide chains across cellular membranes and regulation of protein folding. Heat shock proteins (also known as molecular chaperones) fall into six general families: HSP 90, HSP 70, HSP 60, the low molecular weight HSPs, the immunophilins and the HSP 110 family. The HSP 110 family (also known as the HSP 105 family) is composed of HSP 105, Apg-1 and Apg-2. HSP 105 is a testis-specific and HSP 90-related protein. Research indicates that HSP 105 is specifically localized in the germ cells and may translocate into the nucleus after heat shock. It is suggested that HSP 105 may contribute to the stabilization of p53 proteins in the cytoplasm of the germ cells, preventing the potential induction of apoptosis by p53.

Alternative Name:
HSPH1, HSP105, HSP110, KIAA0201, Antigen NY CO 25, Antigen NY-CO-25, DKFZp686M05240, Heat shock 105kD alpha, Heat shock 105kD, Heat shock 105kD beta, Heat shock 105kDa protein 1, Heat shock 105kDa protein, Heat shock 105kDa/110kDa protein 1, Heat shock 110 kDa protein, Heat shock 110kDa protein, Heat shock protein 105 kDa, HS105, HSP105, HSP105A, HSP105B, HSP110, HSPH 1, Hsph1, KIAA0201, NY CO 25,

Application Dilution:
WB:1:1,000-1:2,000
ICC:1:50-1:200
IHC:1:50-1:200

Specificity: HSP105 polyclonal antibody detects endogenous levels of HSP105 protein.

Immunogen:
recombinant protein

MW: 105 kDa

Swiss-Prot: Q92598(Human) Q61699(Mouse) Q66HA8(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.