Hsp47 polyclonal, anti-human, rat

Quantity: 100 µg

Background:
Heat shock protein 47, also known as SERPINH1 or HSP47, is a serpin which serves as a human chaperone protein for collagen. This protein is a member of the serpin superfamily of serine proteinase inhibitors. Its expression is induced by heat shock. The protein localizes to the endoplasmic reticulum lumen and binds collagen; thus it is thought to be a molecular chaperone involved in the maturation of collagen molecules. Autoantibodies to this protein have been found in patients with rheumatoid arthritis. It has been found that HSP47 monitors the integrity of the triple helix of type I procollagen at the ER/cis-Golgi boundary and, when absent, the rate of transit from the ER to the Golgi is increased and the helical structure is compromised.

Description:
Rabbit IgG polyclonal antibody for Serpin H1 (SERPINH1) detection. Tested with WB, IHC-P in Human, Rat.

Synonyms:
47 kDa heat shock protein antibody, 47 kDa heat shock protein precursor antibody, Arsenic transactivated protein 3 antibody, Arsenic-transactivated protein 3 antibody, AsTP 3 antibody, AsTP3 antibody, CBP 1 antibody, CBP 2 antibody, CBP1 antibody, CBP2 antibody, Cell proliferation-inducing gene 14 protein antibody, Collagen binding protein 1 antibody, Collagen binding protein 2 antibody, Collagen binding protein antibody, Collagen-binding protein 2 antibody, Collagen-binding protein antibody, Colligen antibody, Colligin 1 antibody, Colligin 2 antibody, Colligin antibody, colligin-1 antibody, colligin-2 antibody, gp46 antibody, Heat shock protein 47 antibody, Heat-shock protein 47 antibody, HGNC 1547 antibody, Hsp 47 antibody, J6 antibody, OI10 antibody, PIG 14 antibody, PIG14 antibody, PPROM antibody, Proliferation inducing gene 14 antibody, Proliferation inducing gene 14 protein antibody, RA A47 antibody, RA-A47 antibody, Rheumatoid arthritis antigen A 47 antibody, rheumatoid arthritis antigen A-47 antibody, Rheumatoid arthritis related antigen RA A47 antibody, Rheumatoid arthritis-related antigen RA-A47 antibody, serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) antibody, serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 2, (collagen-binding protein 2) antibody, Serine or cysteine proteinase inhibitor clade H member 1 antibody, Serine or cysteine proteinase inhibitor clade H member 2 antibody, SERPH_HUMAN antibody, Serpin H1 antibody, Serpin peptidase inhibitor clade H member 1 antibody, serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) antibody, Serpin peptidase inhibitor, clade H, member 1 antibody, SERPINH1 antibody, SERPINH2 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human Hsp47 recombinant protein (Position: D247-L418). Human Hsp47 shares 97% amino acid (aa) sequence identity with both mouse and rat Hsp47.E.coli-derived human Hsp47 recombinant protein (Position: D247-L418). Human Hsp47 shares 97% amino acid (aa) sequence identity with both mouse and rat Hsp47.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.