HSP70 (clone BRM-22), anti-human, rat
€455.00
In stock
SKU
AC-ABO10439
Catalog Number: AC-ABO10439
Size: 100 µg
Isotype: Mouse IgG
Applications: WB, IHC-P, IHC-F
Datasheet
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Size: 100 µg
Isotype: Mouse IgG
Applications: WB, IHC-P, IHC-F
Datasheet
Request Information
Description: Mouse IgG monoclonal antibody for HSP70, heat shock 70kDa protein 1A; heat shock 70kDa protein 1B (HSPA1A; HSPA1B) detection. Tested with WB, IHC-P, IHC-F in Human;bovine;rabbit;rat. No cross reactivity with other proteins.Protein Name: Heat shock 70 kDa protein 1A/1B
Protein Function:
In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation. .
Other Names: Heat shock 70 kDa protein 1B, Heat shock 70 kDa protein 1, HSP70.1, Hspa1b, Hcp70.1, Hsp70-1, Hsp70a1, Hspa1
Clone Name(s):
BRM-22
Subcellular Localization: Cytoplasm . Localized in cytoplasmic mRNP granules containing untranslated mRNAs. .
Tissue Specificity: Testis-specific.
Gene ID: 15511
Immunogen: HSP70 isolated from bovine brain.
Calculated MW: 70176
Purification: Ascites
Format: Lyophilized
Reconstitution: Add 1ml of PBS buffer will yield a concentration of 100ug/ml.
Contents: Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.
Concentration (mg/ml): Add 1ml of PBS buffer will yield a concentration of 100ug/ml.
Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.
Protein Function:
In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation. .
Other Names: Heat shock 70 kDa protein 1B, Heat shock 70 kDa protein 1, HSP70.1, Hspa1b, Hcp70.1, Hsp70-1, Hsp70a1, Hspa1
Clone Name(s):
BRM-22
Subcellular Localization: Cytoplasm . Localized in cytoplasmic mRNP granules containing untranslated mRNAs. .
Tissue Specificity: Testis-specific.
Gene ID: 15511
Immunogen: HSP70 isolated from bovine brain.
Calculated MW: 70176
Purification: Ascites
Format: Lyophilized
Reconstitution: Add 1ml of PBS buffer will yield a concentration of 100ug/ml.
Contents: Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.
Concentration (mg/ml): Add 1ml of PBS buffer will yield a concentration of 100ug/ml.
Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.
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