Hsp70 HSPA1A monoclonal, anti-human, mouse, rat
€455.00
In stock
SKU
AC-ABO13643
Catalog Number: AC-ABO13643
Size: 100 µl
Isotype: Rabbit IgG
Applications: WB, IHC, IF, ICC, FC
Datasheet
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Size: 100 µl
Isotype: Rabbit IgG
Applications: WB, IHC, IF, ICC, FC
Datasheet
Request Information
Description: Anti-Hsp70 HSPA1A Rabbit Monoclonal Antibody . Tested in WB, IHC, ICC/IF, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.
Protein Function:
In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223)..
Other Names: Heat shock 70 kDa protein 1A {ECO:0000312|HGNC:HGNC:5232}, Heat shock 70 kDa protein 1, HSP70-1, HSP70.1, Heat shock protein family A member 1A, HSPA1A, HSP72 {ECO:0000303|PubMed:24318877}, HSPA1, HSX70
Clone Name(s):
Clone: DGE-8
Subcellular Localization: Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Gene ID: 3303;3304
Immunogen: A synthesized peptide derived from human Hsp70
Calculated MW: 70052
Purification: Affinity-chromatography
Format: Liquid
Contents: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
Concentration (mg/ml): Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Storage: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Protein Function:
In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223)..
Other Names: Heat shock 70 kDa protein 1A {ECO:0000312|HGNC:HGNC:5232}, Heat shock 70 kDa protein 1, HSP70-1, HSP70.1, Heat shock protein family A member 1A, HSPA1A, HSP72 {ECO:0000303|PubMed:24318877}, HSPA1, HSX70
Clone Name(s):
Clone: DGE-8
Subcellular Localization: Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Gene ID: 3303;3304
Immunogen: A synthesized peptide derived from human Hsp70
Calculated MW: 70052
Purification: Affinity-chromatography
Format: Liquid
Contents: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
Concentration (mg/ml): Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Storage: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
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