HSP70 Polyclonal Antibody

Background:
In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell.

Research Area: Cancer,Signal Transduction

Synonyms:
Heat shock 70 kDa protein 1 antibody, HSP70 1, HSP70 1B, HSP70 2, HSP70-1/HSP70-2, HSP70-1A, HSP70.1/HSP70.2, HSPA1, HSPA1B

Immunogen: Recombinant Mouse Heat shock 70 kDa protein 1B protein

Swissprot: P17879

Calculated MW: 70 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.

Concentration: 2 mg/mL
Dilution: WB 1:500-1:1000, IHC 1:50-1:100

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Citation(s):
https://www.sciencedirect.com/science/article/pii/S014765131930291X
https://pubmed.ncbi.nlm.nih.gov/32251713/