Hsp75 TRAP1 monoclonal, anti-human

Description: Anti-Hsp75 TRAP1 Rabbit Monoclonal Antibody . Tested in WB, IP applications. This antibody reacts with Human.

Protein Function:
Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, most likely through stabilization of mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA..

Other Names: Heat shock protein 75 kDa, mitochondrial, HSP 75, Heat shock protein family C member 5, TNFR-associated protein 1, Tumor necrosis factor type 1 receptor-associated protein, TRAP-1, TRAP1, HSP75, HSPC5 {ECO:0000303|PubMed:18663603}

Clone Name(s):
Clone: IBD-20

Subcellular Localization: Mitochondrion. Mitochondrion inner membrane. Mitochondrion matrix.

Tissue Specificity: Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung, placenta and bladder. Expression is higly reduced in bladder cancer and renal cell carcinoma specimens compared to healthy tissues, but it is increased in other type of tumors..

Gene ID: 10131

Immunogen: A synthesized peptide derived from human Hsp75

Calculated MW: 80110

Purification: Affinity-chromatography

Format: Liquid

Contents: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Concentration (mg/ml): Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Storage: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.