Hsp90 alpha polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
Heat shock protein HSP 90-alpha is a protein that in humans is encoded by the HSP90AA1 gene. The gene, HSP90AA1, encodes the human stress-inducible 90-kDa heat shock protein alpha (Hsp90A). Complemented by the constitutively expressed paralog Hsp90B which shares over 85% amino acid sequence identity, Hsp90A expression is initiated when a cell experiences proteotoxic stress. Once expressed Hsp90A dimers operate as molecular chaperones that bind and fold other proteins into their functional 3-dimensional structures. This molecular chaperoning ability of Hsp90A is driven by a cycle of structural rearrangements fueled by ATP hydrolysis. Current research on Hsp90A focuses in its role as a drug target due to its interaction with a large number of tumor promoting proteins and its role in cellular stress adaptation.

Description:
Rabbit IgG polyclonal antibody for Heat shock protein HSP 90-alpha (HSP90AA1) detection. Tested with WB, IHC-P, ICC in Human, Mouse, Rat.

Synonyms:
D6S182 antibody, FLJ26984 antibody, FLJ31884 antibody, Heat shock 86 kDa antibody, heat shock 90kDa protein 1 alpha antibody, Heat shock protein 90kDa alpha cytosolic class A member 1 antibody, Heat shock protein 90kDa alpha cytosolic class B member 1 antibody, Heat shock protein HSP 90 alpha antibody, Heat shock protein HSP 90 beta antibody, Heat shock protein HSP 90-alpha antibody, HS90A_HUMAN antibody, HSP 84 antibody, HSP 86 antibody, Hsp 90 antibody, HSP84 antibody, HSP86 antibody, Hsp89 antibody, Hsp90 antibody, HSP90 Beta antibody, HSP90A antibody, HSP90AA1 antibody, HSP90AB1 antibody, HSP90B antibody, HSP90N antibody, HSPC1 antibody, HSPC2 antibody, HSPCA antibody, HSPCAL1 antibody, HSPCAL4 antibody, HSPCB antibody, HSPN antibody, LAP2 antibody, Lipopolysaccharide associated protein2 antibody, LPS associated protein 2 antibody, NY REN 38 antigen antibody, Renal carcinoma antigen NY-REN-38 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human Hsp90 recombinant protein (Position: P2-V365). Human Hsp90 shares 99% amino acid (aa) sequence identity with both mouse and rat Hsp90.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB, IHC-P, ICC

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.