HSP90α polyclonal, anti-human, mouse, rat

Background:
The heat shock response was first described for Drosophila salivary gland cells and morphologically consists of a change in their polytene chromosome puffing patterns that involves de novo synthesis of a few proteins. Similar heat shock proteins were later discovered in bacterial chicken and mammalian cells, and have been subsequently studied in other organisms. A series of proteins including HSP 90, HSP 70, HSP 20-30 and ubiquitin are induced by insults such as temperature shock, chemicals and other environmental stress. A major function of HSP 90 and other HSPs is to act as molecular chaperones. HSP 90 forms a complex with glucocorticoid receptor (GR), rendering the non ligand-bound receptor transcriptionally inactive. HSP 90 binds the GR as a heterocomplex composed of either HSP 56 or Cyclophilin D, forming an aporeceptor comiplex. HSP 90 also exists as a dimer with other proteins such as p60/sti1 and p23, forming an apo-receptor complex with estrogen and androgen receptors.

Alternative Name:
HSP 86, HSP86, LAP-2, LPS-associated protein 2, HSP90AA1, EL52, epididymis luminal secretory protein 52, Heat shock 86 kDa, heat shock 90kD protein 1, alpha, Heat shock 90kD protein 1, alpha like 4, heat shock 90kD protein, alpha-like 4, Heat shock 90kDa protein 1 alpha, Heat shock protein 90kDa alpha (cytosolic) class A member 1, Heat shock protein HSP 90-alpha, HS90A, HSP 86, HSP86, Hsp89, HSP89A, Hsp90, HSP90A, HSP90AA1, HSP90ALPHA, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, LAP 2, LAP2, lipopolysaccharide-associated protein 2, LPS-associated protein 2, Renal carcinoma antigen NY-REN-38,

Application Dilution:
WB:1:1,000-1:2,000
ICC:1:50-1:200
IHC:1:50-1:200

Specificity: HSP90α polyclonal antibody detects endogenous levels of HSP90α protein.

Immunogen:
recombinant protein

MW: 90 kDa

Swiss-Prot: P07900(Human) P07901(Mouse) P82995(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.