HSPB8 polyclonal, anti-human, mouse, rat

Background:
The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease.

Synonyms: H11, HMN2, CMT2L, DHMN2, E2IG1, HMN2A, HSP22

Cellular Location: Cytoplasm

Immunogen:
Recombinant protein of human HSPB8

Gene Symbol: HSPB8

Gene ID: 26353

Swiss prot: Q9UJY1

Calculated MW: 22kDa

Recommended dilution:
IHC 1:25-100

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.