HSPG2 polyclonal, anti-human

Quantity: 100 µg

Background:
Perlecan (PLC) also known as HSPG2, is a protein that in humans is encoded by the HSPG2 gene. It is mapped to 1p36.12. Perlecan is highly conserved across species and the available data indicate that it has evolved from ancient ancestors by gene duplication and exonshuffling. Perlecan is a key component of the vascular extracellular matrix, here it interacts with a variety of other matrix components and helps to maintain the endothelial barrier function. It is a potent inhibitor of smooth muscle cell proliferation and is thus thought to help maintain vascular homeostasis. Perlecan can also promote growth factor (e.g., FGF2) activity and thus stimulate endothelial growth and re-generation.

Description:
Rabbit IgG polyclonal antibody for Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG2) detection. Tested with WB, IHC-P in Human.

Synonyms:
Basement membrane specific heparan sulfate proteoglycan core protein antibody, Endorepellin (domain V region) antibody, Heparan Sulfate Proteoglycan antibody, Heparan sulfate proteoglycan of basement membrane antibody, HSPG 2 antibody, HSPG antibody, Hspg2 antibody, LG3 peptide antibody, Perlecan antibody, PGBM_HUMAN antibody, PLC antibody, Schwartz Jampel syndrome 1 (chondrodystrophic myotonia) antibody, SJA antibody, SJS antibody, SJS1 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human HSPG2 recombinant protein (Position: F524-K701). Human HSPG2 shares 86% amino acid (aa) sequence identity with mouse HSPG2.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.