HTRA3 Polyclonal Antibody

Background:
HtrA3, also known as PRSP (pregnancy-related serine protease), is a 453 amino acid secreted protein that contains one PDZ domain, one Kazal-like domain and one IGFBP N-terminal domain. Widely expressed with particularly high expression in ovary, heart, placenta and bladder, HtrA3 functions as a probable serine protease that is thought to play an important role in placental development. HtrA3 is downregulated in ovarian tumors, suggesting an alternative role in tumor suppression. HtrA3 exists as two alternatively spliced isoforms, designated short and long. The gene encoding HtrA3 maps to human chromosome 4, which encodes nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes.

Research Area: Signal Transduction

Synonyms:
High temperature requirement factor A3, High-temperature requirement factor A3, HtrA serine peptidase 3, HTRA3, HTRA3, Pregnancy related serine protease, Pregnancy-related serine protease, Probable serine protease HTRA3, PRSP, Serine protease HTRA3, Tasp

Immunogen: Synthetic peptide of human HTRA3

Swissprot: P83110
Gene Accession: NP_444272

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.2 mg/mL
Dilution: IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-79531/sc-79532/sc-130781