Human Cytokeratin 20, CK20 Recombinant Protein (Active)
€0.00
In stock
SKU
BRP1008
Description: Recombinant full length human Cytokeratin 20 protein with molecular weight 46.6 kDa.
Background:
Keratin 20, also called Cytokeratin 20, CK20, is a protein that in humans is encoded by the KRT20 gene. KRT20 has an apparent molecular mass of about 46 kD. It is a type I cytokeratin. It is a major cellular protein of mature enterocytes and goblet cells and is specifically found in the gastric and intestinal mucosa. KRT20 formed heterotypic complexes with KRT8 in vitro, and the complexes assembled into intermediate filaments under appropriate conditions. The protein is commonly found in colorectal cancer, transitional cell carcinomas and in Merkel cell tumours, but is absent in lung cancer, prostate cancer, and non-mucinous ovarian cancer. It is often used in combination with antibodies to CK7 to distinguish different types of glandular tumour.
Synonyms:
Keratin type I cytoskeletal 20, Cytokeratin-20, CK-20, Keratin-20, K20, KRT20, CK20
Purity: >95% by SDS-PAGE
Storage buffer: Each vial contains Tris-HCL (pH7.4±0.2) with 0.2% sodium azide.
Storage and Expiration:
Ship at 4℃. Upon receipt, aliquot and store at -20℃ or -80℃ for long term. Avoid repeated freeze and thaw cycles
Background:
Keratin 20, also called Cytokeratin 20, CK20, is a protein that in humans is encoded by the KRT20 gene. KRT20 has an apparent molecular mass of about 46 kD. It is a type I cytokeratin. It is a major cellular protein of mature enterocytes and goblet cells and is specifically found in the gastric and intestinal mucosa. KRT20 formed heterotypic complexes with KRT8 in vitro, and the complexes assembled into intermediate filaments under appropriate conditions. The protein is commonly found in colorectal cancer, transitional cell carcinomas and in Merkel cell tumours, but is absent in lung cancer, prostate cancer, and non-mucinous ovarian cancer. It is often used in combination with antibodies to CK7 to distinguish different types of glandular tumour.
Synonyms:
Keratin type I cytoskeletal 20, Cytokeratin-20, CK-20, Keratin-20, K20, KRT20, CK20
Purity: >95% by SDS-PAGE
Storage buffer: Each vial contains Tris-HCL (pH7.4±0.2) with 0.2% sodium azide.
Storage and Expiration:
Ship at 4℃. Upon receipt, aliquot and store at -20℃ or -80℃ for long term. Avoid repeated freeze and thaw cycles
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