Human Emerin (EMD) (clone 5A10) DyLight® 488, anti-human
€600.00
In stock
SKU
AC-ABO14793
Description: Anti-Human Emerin DyLight® 488 conjugated EMD Antibody (monoclonal, 5A10) . Tested in Flow Cytometry applications. This antibody reacts with Human.
Protein Function:
Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta- catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. Required for proper localization of non-farnesylated prelamin-A/C.
Other Names: Emerin, EMD, EDMD, STA
Clone Name(s):
Clone: 5A10
Subcellular Localization: Nucleus inner membrane.
Tissue Specificity: Skeletal muscle, heart, colon, testis, ovary and pancreas.
Gene ID: 2010
Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human Emerin, different from the related mouse sequence by eight amino acids, and from the related rat sequence by nine amino acids.
Calculated MW: 28994
Format: Liquid
Contents: Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
Concentration (mg/ml): 0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Storage: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Protein Function:
Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta- catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. Required for proper localization of non-farnesylated prelamin-A/C.
Other Names: Emerin, EMD, EDMD, STA
Clone Name(s):
Clone: 5A10
Subcellular Localization: Nucleus inner membrane.
Tissue Specificity: Skeletal muscle, heart, colon, testis, ovary and pancreas.
Gene ID: 2010
Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human Emerin, different from the related mouse sequence by eight amino acids, and from the related rat sequence by nine amino acids.
Calculated MW: 28994
Format: Liquid
Contents: Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
Concentration (mg/ml): 0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Storage: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
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