Human Epididymis Recombinant Protein 4, HE4 Recombinant Protein (Active)
€0.00
In stock
SKU
BRP1012
Description: Recombinant full length human HE4 protein with molecular weight 14 kDa.
Background:
WAP four-disulfide core domain protein 2,also known as Human Epididymis Protein 4 (HE4) is a protein that in humans is encoded by the WFDC2 gene. This gene is amplified in ovarian carcinomas, whereas its expression in normal tissues, including ovary, is low. Although the function of the HE4 protein is unknown,it is a member of a family of stable 4-disulfide core proteins that are secreted at high levels.HE4 is a secreted glycoprotein that is overexpressed by serous and endometrioid EOCs(epithelial ovarian carcinomas). Its expression in cortical inclusion cysts suggests that formation of Mullerian epithelium is a prerequisite step in the development of some types ofEOCs.
Synonyms:
Human epididymis protein 4, HE4, WAP four-disulfide core domain protein 2, WFDC2
Purity: >95% by SDS-PAGE
Storage buffer: Each vial contains Tris-HCL (pH7.4±0.2) with 0.2% sodium azide.
Storage and Expiration:
Ship at 4℃. Upon receipt, aliquot and store at -20℃ or -80℃ for long term. Avoid repeated freeze and thaw cycles.
Background:
WAP four-disulfide core domain protein 2,also known as Human Epididymis Protein 4 (HE4) is a protein that in humans is encoded by the WFDC2 gene. This gene is amplified in ovarian carcinomas, whereas its expression in normal tissues, including ovary, is low. Although the function of the HE4 protein is unknown,it is a member of a family of stable 4-disulfide core proteins that are secreted at high levels.HE4 is a secreted glycoprotein that is overexpressed by serous and endometrioid EOCs(epithelial ovarian carcinomas). Its expression in cortical inclusion cysts suggests that formation of Mullerian epithelium is a prerequisite step in the development of some types ofEOCs.
Synonyms:
Human epididymis protein 4, HE4, WAP four-disulfide core domain protein 2, WFDC2
Purity: >95% by SDS-PAGE
Storage buffer: Each vial contains Tris-HCL (pH7.4±0.2) with 0.2% sodium azide.
Storage and Expiration:
Ship at 4℃. Upon receipt, aliquot and store at -20℃ or -80℃ for long term. Avoid repeated freeze and thaw cycles.
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