Human Ferritin (L chain) Recombinant Protein (Active)
€0.00
In stock
SKU
BRP1016
Description: Recombinant full length human ferritin (L chain) protein with molecular weight 20 kDa.
Background:
Ferritin is a ubiquitous intracellular protein that stores iron and releases it in a controlled fashion. It is a protein of 450 kDa consisting of 24 subunits that is present in every cell type. In vertebrates, these subunits are both the light (L) and the heavy (H) type with an apparent molecular weight of 19 kDA or 21 kDA respectively; their sequences are about 50% homologous. Ferritin light chain (FTL) is abnormally expressed in fetuses of both IVF and ICSI, which may contribute to the increase risk of birth defects in these ART. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes. Mutations of the FTL gene cause the rare adult-onset basal ganglia disease also known as neuroferritinopathy.
Synonyms:
Ferritin light chain, Ferritin L subunit, FTL
Purity: >95% by SDS-PAGE
Storage buffer: Each vial contains 10 mM Tris-HCL(pH8.8±0.2) with 0.05% sodium azide.
Storage and Expiration:
Ship at 4℃. Upon receipt, aliquot and store at -20℃ or -80℃ for long term. Avoid repeated freeze and thaw cycles.
Background:
Ferritin is a ubiquitous intracellular protein that stores iron and releases it in a controlled fashion. It is a protein of 450 kDa consisting of 24 subunits that is present in every cell type. In vertebrates, these subunits are both the light (L) and the heavy (H) type with an apparent molecular weight of 19 kDA or 21 kDA respectively; their sequences are about 50% homologous. Ferritin light chain (FTL) is abnormally expressed in fetuses of both IVF and ICSI, which may contribute to the increase risk of birth defects in these ART. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes. Mutations of the FTL gene cause the rare adult-onset basal ganglia disease also known as neuroferritinopathy.
Synonyms:
Ferritin light chain, Ferritin L subunit, FTL
Purity: >95% by SDS-PAGE
Storage buffer: Each vial contains 10 mM Tris-HCL(pH8.8±0.2) with 0.05% sodium azide.
Storage and Expiration:
Ship at 4℃. Upon receipt, aliquot and store at -20℃ or -80℃ for long term. Avoid repeated freeze and thaw cycles.
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