Human GITR Protein, mFc-His tag
€403.00
In stock
SKU
PME100019
Description: Recombinant human GITR protein with C-terminal mouse Fc and 6×His tag
Background:
This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25 (+)CD4 (+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Synonyms: AITR, GITR, TNFRSF18, CD357
Molecular Weight: The protein has a predicted molecular mass of 50-52 kDa after removal of the signal peptide.
Purity: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Buffer: PBS, pH7.4
Buffer: Store at -80°C for 12 months (Avoid repeated freezing and thawing)
Usage: Research use only
Background:
This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25 (+)CD4 (+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Synonyms: AITR, GITR, TNFRSF18, CD357
Molecular Weight: The protein has a predicted molecular mass of 50-52 kDa after removal of the signal peptide.
Purity: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Buffer: PBS, pH7.4
Buffer: Store at -80°C for 12 months (Avoid repeated freezing and thawing)
Usage: Research use only
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