Human Glutamic Acid Decarboxylase65,GAD65Protein
€0.00
In stock
SKU
BRP1103
Description: Recombinant human Glutamic Acid Decarboxylase 65 protein with his tag at N-terminal with molecular weight of 80 kDa.
Background:
Glutamate decarboxylase or glutamic acid decarboxylase (GAD) is an enzyme that catalyzes the decarboxylation of glutamate to GABA and CO2. In mammals, GAD exists in two isoforms encoded by two different genes - GAD1 and GAD2. These isoforms are GAD67 and GAD65 with molecular weights of 67 and 65 kDa, respectively. GAD65 and GAD67 synthesize GABA at different locations in the cell, at different developmental times, and for functionally different purposes. GAD67 is spread evenly throughout the cell while GAD65 is localized to nerve terminals. Gad67 in Drd1a-expressing neurons plays a key role in the development of LID and they support the hypothesis that altered GABAergic neurotransmission in the direct pathway is involved in dyskinesia.
Synonyms:
65 kDa glutamic acid decarboxylase, DCE 2, DCE2, GAD 2, GAD 65, GAD-2, GAD-65, GAD 65, GAD2, Glutamate Decarboxylase 2 (pancreatic islets and brain 65kDa), Glutamate Decarboxylase 2, Glutamate Decarboxylase 65, Glutamate decarboxylase 65 kDa isoform, Glutamic Acid Decarboxylase 2, Glutamic Acid Decarboxylase 65.
Purity: > 85% by SDS-PAGE
Storage buffer: Each vial containsTris-HCl, pH 7.4±0.2 with 0.02% NaN3.
Storage and Expiration:
Ship at 4℃. Upon receipt, aliquot and store at -20℃ for long term. Avoid repeated freeze and thaw cycles.
Background:
Glutamate decarboxylase or glutamic acid decarboxylase (GAD) is an enzyme that catalyzes the decarboxylation of glutamate to GABA and CO2. In mammals, GAD exists in two isoforms encoded by two different genes - GAD1 and GAD2. These isoforms are GAD67 and GAD65 with molecular weights of 67 and 65 kDa, respectively. GAD65 and GAD67 synthesize GABA at different locations in the cell, at different developmental times, and for functionally different purposes. GAD67 is spread evenly throughout the cell while GAD65 is localized to nerve terminals. Gad67 in Drd1a-expressing neurons plays a key role in the development of LID and they support the hypothesis that altered GABAergic neurotransmission in the direct pathway is involved in dyskinesia.
Synonyms:
65 kDa glutamic acid decarboxylase, DCE 2, DCE2, GAD 2, GAD 65, GAD-2, GAD-65, GAD 65, GAD2, Glutamate Decarboxylase 2 (pancreatic islets and brain 65kDa), Glutamate Decarboxylase 2, Glutamate Decarboxylase 65, Glutamate decarboxylase 65 kDa isoform, Glutamic Acid Decarboxylase 2, Glutamic Acid Decarboxylase 65.
Purity: > 85% by SDS-PAGE
Storage buffer: Each vial containsTris-HCl, pH 7.4±0.2 with 0.02% NaN3.
Storage and Expiration:
Ship at 4℃. Upon receipt, aliquot and store at -20℃ for long term. Avoid repeated freeze and thaw cycles.
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