Human Glypican-3, GPC3 Recombinant Protein (Active)
€0.00
In stock
SKU
BRP1021
Description: Recombinant full length human GPC3 protein.
Background:
Glypican 3, GPC3 is a member of the glypican family that are heparan sulfate proteoglycans that bind to the exocytoplasmic surface of the plasma membrane through a covalent glycosylphosphatidylinositol (GPI) linkage. GPC3 gene contains 8 exons and encompasses approximately 500 kb. It encodes a putative extracellular proteoglycan, glypican 3, that is inferred to play an important role in growth control in embryonic mesodermal tissues in which it is selectively expressed. GPC3 acts as a negative regulator of Hedgehog signaling during mammalian development and that the overgrowth observed in SGBS (Simpson-Golabi-Behmel overgrowth syndrome) patients is, at least in part, the consequence of hyperactivation of the Hedgehog signaling pathway.
Synonyms:
Glypican-3, GPC3, GTR2-2, Intestinal protein OCI-5, MXR7, OCI5
Purity: >95% by SDS-PAGE
Storage buffer: Each vial contains 10 mM Tris-HCL(pH8.8±0.2) with 0.05% sodium azide.
Storage and Expiration:
Ship at 4℃. Upon receipt, aliquot and store at -20℃ or -80℃ for long term. Avoid repeated freeze and thaw cycles.
Background:
Glypican 3, GPC3 is a member of the glypican family that are heparan sulfate proteoglycans that bind to the exocytoplasmic surface of the plasma membrane through a covalent glycosylphosphatidylinositol (GPI) linkage. GPC3 gene contains 8 exons and encompasses approximately 500 kb. It encodes a putative extracellular proteoglycan, glypican 3, that is inferred to play an important role in growth control in embryonic mesodermal tissues in which it is selectively expressed. GPC3 acts as a negative regulator of Hedgehog signaling during mammalian development and that the overgrowth observed in SGBS (Simpson-Golabi-Behmel overgrowth syndrome) patients is, at least in part, the consequence of hyperactivation of the Hedgehog signaling pathway.
Synonyms:
Glypican-3, GPC3, GTR2-2, Intestinal protein OCI-5, MXR7, OCI5
Purity: >95% by SDS-PAGE
Storage buffer: Each vial contains 10 mM Tris-HCL(pH8.8±0.2) with 0.05% sodium azide.
Storage and Expiration:
Ship at 4℃. Upon receipt, aliquot and store at -20℃ or -80℃ for long term. Avoid repeated freeze and thaw cycles.
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