Human Interferon beta 1b, IFNβ1b Recombinant Protein (Active)
€0.00
In stock
SKU
BRP1036
Description: Recombinant human IFNβ1b protein with molecular weight 19 kDa.
Background:
Fibroblast interferon, or interferon-beta has 45% homology at the nucleotide level and 29% at the amino acid level with leukocyte interferon, or interferon-alpha. RANKL induces the IFN-beta gene in osteoclast precursor cells, and that IFN-beta inhibits the differentiation of osteoclasts by interfering with the RANKL-induced expression of c-Fos, an essential transcription factor for the formation of osteoclasts. This IFN-beta gene induction mechanism is distinct from that induced by virus, and is dependent on c-Fos itself.
Synonyms:
Leukocyte interferon, B cell interferon, Type I interferon, IFNB1, IFB, IFF, IFNB, IFN-b 1b
Endotoxin level: < 0.1 ng/μg (1 EU/μg) by LAL test
Reconstitution: Reconstitute with sterile 18MΩ-cm H2O.
Dimers: < 1% by SDS-PAGE
Storage buffer: Each vial contains 10 mM Phosphate bufferand 200 mM NaCl(pH7.0) without preservatives.
Storage and Expiration:
Ship at 4℃. Upon receipt, store at -20℃ or -80℃ for 2 years. After reconstituting, it can store at 4℃ for a week, it is recommended to add 0.1% HSA or BSA for long term. Avoid repeated freeze and thaw cycles.
Background:
Fibroblast interferon, or interferon-beta has 45% homology at the nucleotide level and 29% at the amino acid level with leukocyte interferon, or interferon-alpha. RANKL induces the IFN-beta gene in osteoclast precursor cells, and that IFN-beta inhibits the differentiation of osteoclasts by interfering with the RANKL-induced expression of c-Fos, an essential transcription factor for the formation of osteoclasts. This IFN-beta gene induction mechanism is distinct from that induced by virus, and is dependent on c-Fos itself.
Synonyms:
Leukocyte interferon, B cell interferon, Type I interferon, IFNB1, IFB, IFF, IFNB, IFN-b 1b
Endotoxin level: < 0.1 ng/μg (1 EU/μg) by LAL test
Reconstitution: Reconstitute with sterile 18MΩ-cm H2O.
Dimers: < 1% by SDS-PAGE
Storage buffer: Each vial contains 10 mM Phosphate bufferand 200 mM NaCl(pH7.0) without preservatives.
Storage and Expiration:
Ship at 4℃. Upon receipt, store at -20℃ or -80℃ for 2 years. After reconstituting, it can store at 4℃ for a week, it is recommended to add 0.1% HSA or BSA for long term. Avoid repeated freeze and thaw cycles.
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