Human Interferon beta 1b, IFNβ1b Recombinant Protein (Active)

Description: Recombinant human IFNβ1b protein with CKS tag.(MW: 50 kDa)

Background:
Fibroblast interferon, or interferon-beta has 45% homology at the nucleotide level and 29% at the amino acid level with leukocyte interferon, or interferon-alpha. RANKL induces the IFN-beta gene in osteoclast precursor cells, and that IFN-beta inhibits the differentiation of osteoclasts by interfering with the RANKL-induced expression of c-Fos, an essential transcription factor for the formation of osteoclasts. This IFN-beta gene induction mechanism is distinct from that induced by virus, and is dependent on c-Fos itself.

Synonyms:
Leukocyte interferon, B cell interferon, Type I interferon, IFNB1, IFB, IFF, IFNB, IFN-b 1b

Purity: >95% by SDS-PAGE

Endotoxin level: < 0.1 ng/μg (1 EU/μg) by LAL test

Dimers: < 1% by SDS-PAGE

Storage buffer: Each vial contains 20 mM Tris(pH7.2).

Storage and Expiration:
Ship at 4℃. Upon receipt, store at -20℃ or -80℃ for 2 years. After reconstituting, it can store at 4℃ for a week, it is recommended to add 0.1% HSA or BSA for long term. Avoid repeated freeze and thaw cycles.