Human Thyroid peroxidase, TPOProtein
€0.00
In stock
SKU
BRP1125
Description: Recombinant human TPO protein.
Background:
Thyroid peroxidase, also called thyroperoxidase (TPO) or iodide peroxidase, is an enzyme expressed mainly in the thyroid where it is secreted into colloid. In humans, thyroperoxidase is encoded by the TPO gene. Thyroid peroxidase (TPO) deficiency, caused by biallelic TPO mutations, is a well-established genetic form of congenital hypothyroidism (CH). TPO mutations with residual activity are associated with mild TPO deficiency, which is clinically characterized by marked goiter, mild TSH elevation, high serum T3to T4molar ratio, and high serum thyroglobulin levels.
Synonyms:
Thyroid peroxidase, TPO, thyroperoxidase, iodide peroxidase
Purity: >90%by SDS-PAGE
Storage buffer: Each vial contains 20mM Tris-HCl (pH8.0).
Storage and Expiration:
Ship at 4℃. Upon receipt, aliquot and store at -20℃ or -80℃ for long term. Avoid repeated freeze and thaw cycles.
Background:
Thyroid peroxidase, also called thyroperoxidase (TPO) or iodide peroxidase, is an enzyme expressed mainly in the thyroid where it is secreted into colloid. In humans, thyroperoxidase is encoded by the TPO gene. Thyroid peroxidase (TPO) deficiency, caused by biallelic TPO mutations, is a well-established genetic form of congenital hypothyroidism (CH). TPO mutations with residual activity are associated with mild TPO deficiency, which is clinically characterized by marked goiter, mild TSH elevation, high serum T3to T4molar ratio, and high serum thyroglobulin levels.
Synonyms:
Thyroid peroxidase, TPO, thyroperoxidase, iodide peroxidase
Purity: >90%by SDS-PAGE
Storage buffer: Each vial contains 20mM Tris-HCl (pH8.0).
Storage and Expiration:
Ship at 4℃. Upon receipt, aliquot and store at -20℃ or -80℃ for long term. Avoid repeated freeze and thaw cycles.
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