Human Type II Hair Keratins K81-K86 polyclonal, anti-human, mouse

Quantity: 25 µl

Background:
The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix.

Synonyms:
KRT81, HB1, Hb-1, KRTHB1, MLN137, ghHkb1, hHAKB2-1, KRT82, HB2, Hb-2, KRTHB2, hHB2, KRT83, HB3, Hb-3, KRTHB3, hHb3, KRT84, HB4, Hb-4, KRTHB4, hHb4, KRT85, HB5, HB5, Hb-5, KRTHB5, hHb5, KRT86, HB6, Hb-6, KRTHB6, hHb6

Isotype: Guinea pig Polyclonal (pan HKII.2)

Immunogen:
Synthetic peptide common to human type II (basic) hair(trichocytic) keratins K81-K86 (former designation hHb1-hHb6): VNVCVSSSRGGVV-C, coupled to KLH

Form: Stabilized Serum

Specificity:
The antiserum stains specifically human hair keratins K81-K86 present in the hair cortex, hair cuticle and tumors derived therefrom.

Reactivity: human, mouse

Applications: Suitable for immunofluorescence microscopy on frozen sections, immunohistochemistry on frozen sections and paraffin embedded material after microwave pretreatment, immunoblotting (Western)

Working DIlution: 1 : 100 for immunohistochemistry; 1 : 1,000 for Western blotting (ECL)

Storage: 2-8C

References:
- Langbein L, Schweizer J (2005) Intern Rev Cytology 243: 1-78