Human VE-Cadherin CDH5 (clone 3D4) DyLight® 488, anti-human
€600.00
In stock
SKU
AC-ABO14929
Description: Anti-Human VE-Cadherin CDH5 DyLight® 488 conjugated Antibody (monoclonal, 3D4) . Tested in Flow Cytometry applications. This antibody reacts with Human.
Protein Function:
Cadherins are calcium-dependent cell adhesion proteins (By similarity). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (PubMed:21269602). This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions (By similarity). It associates with alpha-catenin forming a link to the cytoskeleton (PubMed:10861224). Acts in concert with KRIT1 and MPP5 to establish and maintain correct endothelial cell polarity and vascular lumen (By similarity). These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B (PubMed:20332120). Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction (PubMed:20332120).
Other Names: Cadherin-5 {ECO:0000312|HGNC:HGNC:1764}, 7B4 antigen, Vascular endothelial cadherin, VE-cadherin, CD144, CDH5 (HGNC:1764)
Clone Name(s):
Clone: 3D4
Subcellular Localization: Plasma membrane
Gene ID: 1003
Immunogen: E. coli-derived human VE Cadherin recombinant protein (Position: D48-R272).
Calculated MW: 87528
Format: Liquid
Contents: Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN7.
Concentration (mg/ml): 0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Storage: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Protein Function:
Cadherins are calcium-dependent cell adhesion proteins (By similarity). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (PubMed:21269602). This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions (By similarity). It associates with alpha-catenin forming a link to the cytoskeleton (PubMed:10861224). Acts in concert with KRIT1 and MPP5 to establish and maintain correct endothelial cell polarity and vascular lumen (By similarity). These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B (PubMed:20332120). Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction (PubMed:20332120).
Other Names: Cadherin-5 {ECO:0000312|HGNC:HGNC:1764}, 7B4 antigen, Vascular endothelial cadherin, VE-cadherin, CD144, CDH5 (HGNC:1764)
Clone Name(s):
Clone: 3D4
Subcellular Localization: Plasma membrane
Gene ID: 1003
Immunogen: E. coli-derived human VE Cadherin recombinant protein (Position: D48-R272).
Calculated MW: 87528
Format: Liquid
Contents: Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN7.
Concentration (mg/ml): 0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Storage: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
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