HUS1 polyclonal (C-term), anti-human
€0.00
In stock
SKU
AC-AP16922b
Catalog Number: AC-AP16922b
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB36257
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB36257
Applications: WB
Datasheet
Request Information
Background:
The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. [provided by RefSeq].
Other Names:
Checkpoint protein HUS1, hHUS1, HUS1
Target/Specificity:
This HUS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 199-226 amino acids from the C-terminal region of human HUS1.
Antigen Region:
199-226
Antigen Type: Synthetic Peptide
Gene Name: HUS1
Gene ID: 3364
Primary Accession: O60921
NCBI Accession: NP_004498.1
Other Accession: NP_004498.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. [provided by RefSeq].
Other Names:
Checkpoint protein HUS1, hHUS1, HUS1
Target/Specificity:
This HUS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 199-226 amino acids from the C-terminal region of human HUS1.
Antigen Region:
199-226
Antigen Type: Synthetic Peptide
Gene Name: HUS1
Gene ID: 3364
Primary Accession: O60921
NCBI Accession: NP_004498.1
Other Accession: NP_004498.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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