HYAL1 Polyclonal Antibody

Background:
This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene.

Research Area: Cancer, Signal Transduction

Synonyms:
HYAL1, HYAL-1, LUCA1, MPS9, NAT6

Immunogen: Recombinant fusion protein of human HYAL1 (NP_149349.2).

Swissprot: Q12794
Gene ID: 3373

Calculated MW: 10 kDa/19 kDa/23 kDa/27 kDa/37 kDa/45 kDa/48 kDa
Observed MW: 48 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000 IHC 1:50-1:200"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.