HYAL2 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
HYAL2(hyaluronoglucosaminidase 2) also known as hyaluronidase 2, LuCa-2, is an enzyme that in humans is encoded by the HYAL2 gene. HYAL2 cDNAs encode a preprotein with an N-terminal signal peptide. Northern blot analysis indicated that HYAL2 was expressed in all human tissues tested except adult brain, and Western blot analysis detected Hyal2protein in all mouse tissues examined except adult brain. The HYAL2 gene is mapped on 3p21.31. HYAL2 is a glycosylphosphatidylinositol(GPI)-anchored protein on the cell surface and serves as a receptor for entry into the cell of the jaagsiekte sheep retrovirus(JSRV). The findings of Rai et al.(2001) that HYAL2 is a GPI-anchored protein on the cell surface showed that GFP would likely be cleaved from HYAL2 during GPI addition, leaving HYAL2 on the cell surface and resulting in GFP transit to the lysosome for degradation.

Description:
Rabbit IgG polyclonal antibody for Hyaluronidase-2 (HYAL2) detection. Tested with WB in Human, Mouse, Rat. .

Synonyms:
Hyal 2 antibody, Hyal-2 antibody, Hyal2 antibody, HYAL2_HUMAN antibody, Hyaluronidase 2 antibody, Hyaluronidase 2 Precursor antibody, Hyaluronidase-2 antibody, Hyaluronoglucosaminidase 2 antibody, Hyaluronoglucosaminidase-2 antibody, LUCA 2 antibody, LUCA-2 antibody, LUCA2 antibody, Lung carcinoma protein 2 antibody, lysosomal hyaluronidase antibody, PH 20 homolog antibody, PH-20 homolog antibody, PH20 homolog antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human HYAL2(142-157aa VRNWQDKDVYRRLSRQ), different from the related mouse and rat sequences by three amino acids.A synthetic peptide corresponding to a sequence at the C-terminus of human HYAL2(142-157aa VRNWQDKDVYRRLSRQ), different from the related mouse and rat sequences by three amino acids.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat .
Predicted to work with: mouse.

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.