Hydroxysteroid(17-beta) Dehydrogenase 4 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
The HSD17B4 gene encodes an enzyme involved in peroxisomal fatty acid beta-oxidation. It was first identified as a 17-beta-estradiol dehydrogenase. Peroxisomal beta-oxidation of fatty acids is catalyzed by 3 enzymes: acyl-CoA oxidase; the D-bifunctional enzyme with enoyl-CoA-hydratase and D-3-hydroxyacyl-CoA dehydrogenase activity, and 3-ketoacyl-CoA thiolase. The D- and L-bifunctional proteins have different substrate specificities. The D-bifunctional protein catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids and also acts in shortening cholesterol for bile acid formation. In contrast, the L-specific bifunctional protein does not have the latter 2 activities.

Description:
Rabbit IgG polyclonal antibody for (3R)-hydroxyacyl-CoA dehydrogenase (HSD17B4) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase antibody, 17 beta HSD 4 antibody, 17 beta HSD IV antibody, 17 beta hydroxysteroid dehydrogenase 4 antibody, 17-beta-HSD 4 antibody, 17-beta-hydroxysteroid dehydrogenase 4 antibody, 17beta estradiol dehydrogenase type IV antibody, 3 alpha 7 alpha12 alpha trihydroxy 5 beta cholest 24 enoyl CoA hydratase antibody, 3-alpha antibody, 7-alpha antibody, Beta hydroxyacyl dehydrogenase antibody, Beta keto reductase antibody, D 3 hydroxyacyl CoA dehydratase antibody, D bifunctional protein antibody, D bifunctional protein peroxisomal antibody, D-bifunctional protein antibody, DBP antibody, DHB4_HUMAN antibody, EDH17B4 antibody, Enoyl-CoA hydratase 2 antibody, Hsd17b4 antibody, MFE 2 antibody, MFE-2 antibody, MPF-2 antibody, Multifunctional protein 2 antibody, Peroxisomal multifunctional enzyme type 2 antibody, Peroxisomal multifunctional protein 2 antibody, SDR8C1 antibody, Short chain dehydrogenase/reductase family 8C member 1 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human Hydroxysteroid(17-beta) Dehydrogenase 4(744-761aa NIMLSQKLQMILKDYAKL), identical to the related rat and mouse sequences.A synthetic peptide corresponding to a sequence at the C-terminus of human Hydroxysteroid(17-beta) Dehydrogenase 4(744-761aa NIMLSQKLQMILKDYAKL), identical to the related rat and mouse sequences.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat .
Predicted to work with: mouse.

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.