I-Ab,k (MHC Class II) (clone NR-D11) biotin, anti-mouse

Background:
This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction.

Decription:
Mouse monoclonal Antibody to Mouse I-Ab,k (MHC Class II), Biotin conjugate

Synonyms: C2TA, MHC2TA, NLRA

Clone: NR-D11

Isotype: Mouse IgG2a

Immunogen: Purified Mouse lymph node B cells

Reactivity: mouse

Specificity: Mouse I-Ab,k. Some cross reaction was detected with I-Au.

Form: Affinity Purified, in PBS containing 0.5% BSA and 0.1% Sodium Azide

Applications: Staining, sorting, panning, antibody mediated cytotoxicity and immunoprecipitation

Storage: 2-8C for immediate use; or at -20C (aliquot) Avoid freeze-thaw cycles