IAPP Polyclonal Antibody

Background:
Islet, or insulinoma, amyloid polypeptide is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. While the association of amylin with the development of type II diabetes has been known for some time, a direct causative role for amylin has been harder to establish. Studies suggest that amylin, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes.

Research Area: Cancer, Cardiovascular, Metabolism, Signal Transduction

Synonyms:
Amylin, DAP, Diabetes associated peptide, Diabetes-associated peptide, IAP, IAPP, IAPP, Insulinoma amyloid peptide, Islet amyloid polypeptide (diabetes associated peptide, amylin), Islet amyloid polypeptide

Immunogen: Synthetic peptide of human IAPP

Swissprot: P10997
Gene Accession: NP_000406

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.8 mg/mL
Dilution: IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-20936